Endocrine Abstracts

In our study during the period of 6 months we were monitoring lactate and other biochemical parameters levels in patients with diabetes mellitus and myocardial infarction after introducing Metformin into their treatment protocols.Fifteen persons with the DM 2 (eight males and seven females) were included into the first group. Metformin was administrated in a daily dosage of 1700 mg. Some patients (7/15) were receiving antidiabetic therapy with the sulpho...

In presence of androgen gene mutation, leading to androgen insensitivity because of an impaired regulatory mechanism of the gonadotropin–androgen axis, both LH and T in serum may be elevated, leading to a distinctively high value of the LH×T multiplication product, which has been termed as the androgen sensitivity index (ASI). The aim of our present study was to investigate a cohort of young males for impaired ASI. One hundred and seventy-seven nearly healthy post-pu...

Diabetes mellitus and abdominal obesity are considered to be risk factors for venous and arterial thrombosis, but till now it still remains unclear, what factor is a primary in the genesis of these abnormalities: fibrinolysis dysfunction, vascular endothelium impairment or pathology of the platelet homeostasis component.Forty-two persons included in the study were primary divided into 3 groups: 1 group – nearly healthy (10 males, 12 females), 2 grou...

Androgen insensitivity leads to a defect of virilization in karyotypic males despite supraphysiologic androgen levels. Because of an impaired regulatory mechanism of the gonadotropin-androgen axis, both LH and T in serum may be elevated, leading to a distinctively high value of the LH×T multiplication product, which has been termed as the androgen sensitivity index (ASI). The aim of our present study was to investigate a cohort of young males with light decrease in penile...

Object of the study: To evaluate total testosterone (TT) levels in healthy young men and determine its possible influence on metabolic syndrome risk factors.Materials and methods: One hundred and twenty-six practically healthy young men, mean age 20.16±1.42 years old (18–29) were included in the study. Individuals with any clinical manifestations suspicious for hypogonadism, chronic liver and kidney diseases in the anamnesis or receiving any ki...

The phosphodiesterase inhibitor pentoxifylline (PTX) is known to have immunomodulatory effects in some autoimmune diseases. The aim of our study was to assess the influence of glucocorticoids monotherapy and additive treatment with PTX on peripheral blood mononuclear cells (PBMC) proliferation and apoptosis in patients with Graves’ ophthalmopathy (GO).Eighteen patients with GO and 28 healthy controls were investigated. GO patients were divided into ...

Pentoxifylline (PTX), a phosphodiesterase inhibitor, has a positive therapeutic effect in some autoimmune diseases due to immunomodulatory action.The aim of the study was to assess the influence of PTX on apoptosis and peripheral blood mononuclear cells (PBMC) proliferation in patients with Graves’ ophthalmopathy (GO).Twenty-four patients with GO and 32 healthy controls were investigated. GO patients were divided into two grou...